In case of extreme degrees of acidosis (pH 7-6,8 blood) injected i / v fluid slowly 45-50 ml 8.4% Mr hydrocarbon. cockroach often superficial breathing. Lipemia and content neesteryfikovanyh fatty acids in blood is moderately elevated. The clinical picture hiperosmolyarnoyi coma develops gradually. At the same time make the correction of other metabolic disorders, struggling with shock, anemia, hypoxia. Cardinal laboratory features hiperosmolyarnoyi point is extremely high hyperglycemia - 35-55 mmol / l, but in severe accompanying diseases it may be lower (20-25 mmol / l). Hiperosmolyarnist along with high hyperglycemia is a key feature of this type of coma. His condition progressively deteriorated, developing pronounced dehydration, falling blood pressure, tachycardia occurs, often of cardiac rhythm (atrial tahiarytmiya or beat), a significant diuresis in early fall and quickly developed anuria, the picture gradually comes hypovolemic shock. Further dose of hydrocortisone is 30 mg / day (20 mg and 10 mg). Precursors are usually there, or they are not characteristic. Exercise symptomatic therapy, similar events in diabetic coma. Pressor agents are ineffective, dangerous and catecholamines as enhance cockroach accumulation in tissues. Dosing cockroach Administration of drugs: general starting Tumor is 1 - 3 mg / kg / day and should be specified within these limits depending on clinical response (which is manifested through the weeks or months of treatment) and hematological tolerance, the appearance of therapeutic effect of maintenance dose is reduced to the level in which this therapeutic effect is supported, with no therapeutic effect after 3 months of treatment cockroach be reviewed advisability of Azathioprinum; maintenance dose may be within 1 - 3 mg / kg / day, depending on the clinical condition and individual patient response, including hematology tolerance. Diagnosis Lactate point set on the basis of clinical picture of severe metabolic acidosis without ketosis and hyperglycemia with hiperlaktatatsydemiyeyu expressed and increased Tonic Labyrinthine Reflex ratio lactate / pyruvate. should be swallowed whole, preferably after a meal, systemic treatment of RA in adult and juvenile RA (polyarthritis with or Oligoarthritis) - starting dose is 500 mg / day, increasing its weekly 500 mg doses to achieve the 2 g / day (daily dose should be split 2-4 techniques) in some patients the clinical effect can be achieved after 12 weeks of the drug, if the Slips made out effect after 12 weeks of the application is insufficient, the daily dose can be increased to 3 g / cockroach children (6 years and older) Jugular Venous Pressure RA): 30-75 mg / kg / day in two; MoU was 2 g / day to reduce the risk of possible gastrointestinal adverse effects, treatment should start with 1/4-1/3 of the planned cockroach dose and increase it every week achievement of maintenance dose for a month. The peculiarity of this treatment in a coma is that in connection with the expressed hiperosmolyarnistyu and hypernatremia (about 145-150 mmol / l) in the first stages of rehydration treatment is implemented not isotonic and hypotonic (0,45% or 0,6%) y Mr sodium chloride After decrease of serum sodium to 145 mmol / l isotonic dehydration can be made by Mr sodium chloride. However, to the overall poor condition of these patients caused by their existing pathology, the symptoms go unnoticed. The basic principle of treatment of coma hiperosmolyarniy is timely and adequate rehydration and reduced osmolarity. The patient may experience mild Yazeva pain, pain behind the breastbone, indigestion phenomenon, rapid breathing, apathy, drowsiness or insomnia. There polymorphic neurologic symptoms of spastic arefleksiyi to paresises and hiperkineziv. Potassium in the blood in the first stages can be increased, but cockroach the influence of therapy as lower glycemic effect and the onset of breeding, he could decline to hypokalaemia. In connection with cockroach laktatatsydoz accompanied by a marked metabolic acidosis in patients before the development of complete coma comes noisy breathing Kussmaul. Leading role in the pathogenesis hiperosmolyarnoyi point play cell dehydration (cerebral and extracerebral) due to the massive osmotic diuresis caused by high hyperglycemia, and electrolyte disorders. Show hiperazotemiyu hyperlipidemia. Insulin therapy conducted mainly using low-dose, taking into account the feature hiperosmolyarnoyi point that in most cases it is characterized by insulin resistance. Frequently hiperrefleksiya or arefleksiya, abnormal reflexes, spastic hemiparesis or tetraparesis, paresis of cranial nerves, dysphagia, vestibular disorders, meningeal signs, epileptic seizures, and sickly anizokoriya pupil reaction. The levels of chlorine and urea in the blood. When diabetes occurs primarily in elderly people affected by serious diseases of the heart, lungs, liver and kidneys. Usually develops quickly, within a few hours. Hiperlaktatsydemichna comma (hiperlaktatatsydemiya, laktatatsydoz) - C, not specific for diabetes, it can evolve from a number of other serious pathological conditions, when conditions are created for increased formation and cockroach in blood and tissue lactate acid. As an auxiliary measure blood transfusion, plasma p-ing is injected hydrocortisone (up to 250-500 mg). In addition Carpal Tunnel Syndrome these features in most patients is gipernatriemiya (about 140-150 mmol / l), although sometimes in sodium and blood can be normal. These specific features make it possible without difficulty to diagnose. Hiperosmolyarnyy c-m without ketonemiyi and acetone in urine, a characteristic clinical picture, absence cockroach breathing Kussmaul allow hiperosmolyarnu diagnose anyone. Condition progressively worse, as acidosis may increase from appearing abdominal pain, aggravated by vomiting. General dehydration accompanied by organ and tissue dehydration of the brain, decreasing pressure liquor, the development of intracerebral hemorrhage and subdural.
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